Chronic Inflammation

The Common Denominator of All Disease?

What is Chronic Inflammation (CI)?

Inflammation is a protective response to trauma, infection, and allergens

Acute inflammation has a rapid onset and usually resolves in hours to days

CI can cause damage to healthy tissues and cells due to prolonged stress

Chronic inflammation occurs when the inflammatory response persists, and lasts for months to years

Hallmark symptoms of CI include redness, swelling, soreness, warmth and loss of function

Chronic inflammation has been called the 21st century’s “Silent Killer” because it leads to difficult-to-diagnose internal tissue damage and a wide range of diseases
Chronic inflammation has been called the 21st century’s “Silent Killer” because it leads to difficult-to-diagnose internal tissue damage and a wide range of diseases

Which Conditions Are Linked To Chronic Inflammation?

Neurodegenerative Disorders like Parkinson’s, ALS/MND, and Alzheimer’s
Asthma
Heart Disease
Allergies
Cancer
Obesity
Arthritis
Diabetes
Inflammatory Bowel Disease

What Are The Causes of Chronic Inflammation?

Diet

Autoimmune disorder

Persistent infection

Lack of exercise

Free radical exposure

Smoking

How To Prevent Chronic Inflammation?

Exercise and weight loss
Adequate Sleep
Anti-inflammatory foods
Anti-inflammatory drugs like metformin, statins, and NLRP3 inflammasome inhibitorsquate Sleep
RRx-001:

NLRP3 Inflammasome Inhibitor

Direct inhibition of the inflammasome by RRx-001 shows promise for the treatment and prevention of chronic inflammation driven diseases. Preclinical studies are underway to address a long list of inflammation (inflammasome) regulated disorders.

What is the inflammasome?

The inflammasome is a protein structure responsible for the activation of inflammatory responses

TONY REID, M.D. Ph.D.

Chief Executive Officer & Chief Scientific Office

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FRANCK BRINKHAUS, Ph.D.

Chief Financial Officer

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BRYAN ORONSKY, M.D. Ph.D.

Chief Medical Officer

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CHRIS LARSON,
M.D. Ph.D.
Vice President of Viral Therapy

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MEAGHAN STIRN,
M.B.A
Controller & VP of Special Projects

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SCOTT CAROEN
Senior Director of Operations & Corporate Development

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Rajan Kumar
ESQ
Chief Executive Officer & Chief Scientific Office

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Control inflammation & control the disease

RRx-001 inhibits the inflammasome

The Inflammasome is responsible for activation of inflammatory responses. With chronic inflammation tissue destruction that occurs outpaces the regeneration of damaged tissues. Eventually, over time, the normal function of these tissues is reduced or lost. In chronically inflamed tissues, which may result from unresolved sources of foreign bodies, irritants or infections, the inflammasome fuels an inflammatory response for weeks to months or even years, resulting in a range of metabolic, neurological, autoimmune disorders as well as in the initiation of cancer.
The Answer: AdAPT-001 programs infected cancer cells to produce a TGFβ “trap” molecule that is designed to neutralize TGFβ within the infected tumor. Eliminating the t-cell silencing TGFβ protein allows for the immune system to remain activated against cancer, making AdAPT-001 unlike any other immunotherapy.
AdAPT-001 doesn’t just create a cancer targeted infection, it produces a proprietary TGFβ “trap” protein to eliminate this tumor defense mechanism and allow for sustained immune response against cancer – alone or in combination with immune checkpoint inhibitors.
Neurodegenerative Disorders like Parkinson’s, ALS/MND, and Alzheimer’s
Asthma
Heart Disease