“Actor and comedian, Marty Feldman (below), from Young Frankenstein was the definition of swivel-eyed.” Swivel-eyed Definition (adjective) chiefly British slang: having extreme, deranged, or fanatical views “He is a swivel-eyed fanatic”; “They are a bunch of...
General
Cancel Culture
Sorry Elon Musk, but we unreservedly support cancel culture. Oh yes, we most certainly do. But, keep reading, Elon et al., we’re not talking along any ideological or partisan lines here. The culture in question is the proprietary suspension of cells that we use to...
Misfortune Cookie
EpicentRx Word of the Week (WOW): Cromulent
“This definition of cromulent is perfectly cromulent.” Cromulent Definition (adjective): acceptable, fine, or legitimate. “Cromulent is a perfectly cromulent word.” Pronunciation: kraa-myuh-luhnt About the Word: Cromulent is a nonsense word...
EpicentRx Word of the Week (WOW): Solecism
"It is bad grammer not to know the word solecism." Solecism Definition (noun): 1) a grammatical mistake “to say we done it instead of we did it is a solecism” 2) a faux pas, a gaffe, bad manners “it is a social solecism to ask someone how much money they earn.”...
At Symbol
Ever stop to consider, as we did this morning for no apparent reason, that the interesting symbol @ has the most atrociously unimaginative and booooring name ever: at? This is no offense to AT, the uber-talented, cool, and creative MCS Healthcare PR point person,...
Next Jen
Here’s our word of the weak, spelling intentional: next gen. This is the cringeworthy, empty phrase overused by the “fake it until you make it” crowd to describe cars, cellular service, software, and even pharmaceuticals. Why say “advanced”, “innovative” or...
American Physiology Summitt
April 2024 - Long Beach, California Learn more
Lyse!
LICE! Ugh! #Gross! #Disgusting! #Horrible! Or, dare we say it, #lousy! For most parents a plague of locusts, waves of frogs, a pestilence of boils, or three days of uninterrupted darkness are preferable to a lice infestation, which is their - and let’s face it...
EpicentRx Word of the Week: Eustress
“I stress. You stress. We all scream for eustress.” Eustress Definition (noun): a positive or beneficial form of stress. It is the opposite of distress or negative stress. Pronunciation: yoo-stress Example sentences: “Exercise is a form of...
Hot or Not?
From time to time in this space, we will apply the phrase “Hot or Not?” to tumors from cases that we know or read about. This is clinically relevant because tumors that are hot or immune-infiltrated tend to respond better to therapies. It is the goal of EpicentRx lead...
Anti-Inflammaging: A Modern-Day Fountain of Youth
By: Bryan Oronsky, Ahad Javansalehi “Who wants to live forever?” -Freddie Mercury Introduction A common phrase that adults use with hyperactive children is “act your age!”. However, for hypoactive middle-aged and older adults, the best advice is “don’t act your age”....
Care-ismatic
If we were to describe Dr. Tony Reid, CEO, and founder of EpicentRx, whip-smart Professor Emeritus of Gastrointestinal (GI) Oncology at the University of California at San Diego (UCSD), and all-around great, great person, really and truly he is, in a single, solitary...
Nobody Does it Beta
From the Spy who Loved me, Carly Simon sang what is, bar none, in our humble opinion, the greatest James Bond theme song ever composed, “Nobody Does It Better”. Change the opening stanza from “better” to “TGF-beta” and it describes not 007 but 001, as in AdAPT-001:...
Show and Tell
One of the most earnestly endearing collection of essays ever written is entitled, “All I Really Need to Know I Learned in Kindergarten” by the Unitarian minister and best-selling author, Robert Fulghum. The book published almost 40 years ago in 1986 but the life...
EpicentRx To Attend the American Physiology Summit (APS)
No per-APS about it. EpicentRx is a definite for the American Physiology Summit (APS) from April 4-7 in Long Beach, California where the UCSD bioengineering lab of Dr. Pedro Cabrales will present 3 posters on its lead small molecule, RRx-001 (nibrozetone). The titles...
Blogging About Clogging
This is a companion post to a recently written one entitled, “Blogging About NO Clogging.” That post describes how the EpicentRx lead small molecule, RRx-001 (nibrozetone), releases the gaseous vasodilator, nitric oxide (NO), only under hypoxic/ischemic conditions to...