Why did we spell “smog” like “sm-AH-g” in the title?
Well, if you made it past that first sentence, it’s not to imitate a “Bahston” accent from, say, Matt Damon, Ben Affleck, or Mark Wahlberg, even though we have been known to say, “Pahk yah cah in Hahvahd Yahd” and “Wicked Pissah,” meaning really awesome, once or twice.
This post follows two others entitled, “A Blog About Smog,” and “A Blog About Smaug,” in which we describe the mechanism of action of lead EpicentRx therapy, RRx-001 (nibrozetone) as “smog-like” because it releases key components of smog, nitric oxide (NO) and nitric acid (HNO3), in and around poorly oxygenated, diseased tissues like tumors and atherosclerotic or stenotic blood vessels.
RRx-001 (nibrozetone) is an admittedly complex small molecule with multifaceted mechanisms of action.
So, when we showed these two posts, “A Blog About Smog” and “A Blog About Smaug” to two individuals, both non-scientists, a light bulb apparently went on because they smiled and said, “AH! We get it now. Before we didn’t.”
Which was, yes, we understand, an incredibly roundabout way to explain why this post is titled, “A Blog About Sm-AH-g”. Sorry. 🙇 (And in case it’s still not clear, the “AH!” in “Sm-AH-g” refers to the moment of epiphany.)
Still, to anyone who might have thought that we weren’t up to the task of explaining the nuances of RRx-001 in relatively simple terms, all we can say is, “How do you like them apples?” 🍏🍏🍏
The phrase “wicked pissah” also applies.
Meantime, look out for another incredibly – sarcasm intended – concise, and very to-the-point, post tomorrow or, as they say in Boston, “tamorrah.”