by EpicentRx | Jan 19, 2024 | Blog
The American Heritage Dictionary defines a bog as “an area of soft, naturally waterlogged ground.” By this definition, many tumors qualify as bog- or swamp-like i.e., they are “Bogstacles” given the degree to which blood flow through them is not only sluggish but also...
by EpicentRx | Jan 17, 2024 | Blog
Go big or go home. Live large. Think big. Hit the bigtime. In general, we are conditioned to think that bigger is better. This is also true in drug development where the recent focus has moved away from small molecules to large ones such as monoclonal antibodies, and...
by EpicentRx | Jan 16, 2024 | Blog
The two most advanced indications for RRx-001 (nibrozetone) are in oncology as a chemosensitizer for the treatment of small cell lung cancer (SCLC) (Phase 3 REPLATINUM) and as a chemoradioprotector for the mitigation of severe oral mucositis (SOM) (Phase 2b KEVLARx)....
by EpicentRx | Jan 15, 2024 | Blog
“What’s the storia with aporia?” “Don’t be in doubt about the meaning of aporia.” Aporia noun uh-poor-ee-uh Aporetic adjective Definition: an expression of skepticism or doubt. an irresolvable paradox. Example sentences: “Two classic aporias or insoluble questions are...
by EpicentRx | Jan 12, 2024 | Blog, General
This is a companion post to a recently written one entitled, “Blogging About NO Clogging.” That post describes how the EpicentRx lead small molecule, RRx-001 (nibrozetone), releases the gaseous vasodilator, nitric oxide (NO), only under hypoxic/ischemic conditions to...
