At EpicentRx™ we’re focused on Remission:
Possible through the development of novel therapies designed to target inflammatory diseases and supportive care conditions of unmet medical need.
Tony Reid, M.D. Ph.D.
EpicentRx Chief Executive Officer
30-year practicing GI oncologist
PRETECT Platform
The Phase 3 investigational product, RRx-001 is from a portfolio that targets inflammatory and supportive care unmet medical needs.
AdAPT Platform
eLoop Device
Explore our Pipeline
Introducing PRETECT Platform lead clinical candidate RRx-001
See what makes RRx-001 different
Control inflammation, control the disease
RRx-001 inhibits the inflammasome
Conferences
AHA (American Heart Association) Scientific Sessions 2022
November 5-7 , 2022 – McCormick Place, Chicago, IL
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American Society of Clinical Oncology (ASCO)
May 31-June 4, 2024 – Chicago, Illinois
Oral Presentation: Phase 1/2 study of the TGF-β-trap-enhanced oncolytic adenovirus, AdAPT-001, plus an immune checkpoint inhibitor for patients with immune refractory cancers.
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American Physiology Summitt
April 2024 – Long Beach, California
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American Association for Cancer Research (AACR)
April 2024 – San Diego, California
Poster Session: Improved clinical outcomes in patients received treatment beyond tumor progression with AdAPT-001 +/- a checkpoint inhibitor
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Precision Medicine World Conference
January 2024; Silicon Valley, California
Oral Presentation: AdAPT-001 in Advanced Soft-Tissue Sarcoma (BETA PRIME)
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Oncolytic Virotherapy Summit 2023
December 2023; Boston, MA
Oral Presentation: Evaluating the Advantages & Hurdles of Intratumoral Delivery of Oncolytic Viruses
Inflammasome Therapeutics Summit
November 2023; Boston, Massachusetts
Oral Presentation: The Exploring the Development of RRx-001: the NLRP3 Small Molecule Inhibitor for a Variety of Inflammatory Diseases
Neuroscience 2023
November 2023; Washington D.C.
Oral Presentation: The CNS-permeable NLRP3 inhibitor RRx-001 is neuroprotective in experimental models of Parkinson’s disease
American Society of Clinical Oncology (ASCO) Annual Meeting 2023
June 2023; Chicago, Illinois
Poster: RRX-001 Initial results from a first in human dose escalation trial of a novel immune stimulating oncolytic adenovirus, AdAPT-001 TGF-ß Trap (NCT04673942)
Poster: RRX-001, KEVLARx: A phase 2b, multi-institutional, randomized, blinded, controlled trial to assess the safety and efficacy of two schedules of RRx-001 vs. SOC in attenuating severe oral mucositis (SOM) in patients receiving concomitant chemoradiation (CRT) for the treatment of locally advanced squamous cell carcinomas (SCC) of the oral cavity (OC) or oropharynx (OPC).
AD/PD 2023 (Alzheimer’s & Parkinson’s Diseases International Conference)
March 2023, Gothenburg Sweden
Oral Presentation: RRx-001, A Direct NLRP3 Inhibitor and Phase 3 Small Molecule Improves Alzheimer’s and Parkinson’s Pathology in Multiple Disease Models
SITC 2023 Spring Scientific
March 2023, Denver Colorado
Poster: TRIAL-IN-PROGRESS BETA-PRIME: Phase I study of AdAPT-001 as monotherapy and combined with a checkpoint inhibitor in superficially accessible, treatment-refractory solid tumors (NCT04673942)
Poster: Low dose but not high dose RRx-001 repolarizes tumor associated macrophages from an M2 to M1 phenotype in colorectal cancer
American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium
February 2023, San Francisco, California
Poster: Effect of RRx-001 on nephrotoxicity of cisplatin/etoposide in patients with solid tumors
3rd TGF-B for Immuno-Oncology Drug Development Summit 2023
January 2023, San Francisco, California
Oral Presentation: Exploring the Clinical Stage TGF-β Fusion Protein Expressing Oncolytic Virus, AdAPT-001
- Highlighting the safety and tolerability of TGF-β targeting OV, AdAPT-001
- Using correlative studies for measuring expression in the clinic
- Discussing neutralizing TGF-β for improving checkpoint inhibitors
American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium 2023
January 2023, San Francisco, California
Poster: Phase 2 randomized, active-controlled, multicenter trial to assess the safety and efficacy of RRx-001 + irinotecan vs. regorafenib + irinotecan in third/fourth-line colorectal cancer.
San Antonio Breast Cancer Summit (SABCS) 2022
December 2022, San Antonio, Texas
Poster: Treatment of 4T1 Breast Cancer with Liposome-Encapsulated AdAPT-001, a TGF-beta Trap Encoded Oncolytic Adenovirus Currently in a Phase 1/2 Anticancer Trial
4th Inflammasome Therapeutics Summit 2022
November 2022, Boston, Massachusetts
Oral Presentation: RRx-001, a Small Molecule Anticancer Agent in Phase 3, Protects Against Inflammasome-Driven Diseases
- Evaluate strategy and execution of drug design and translational development
- Understanding relevant pathology of disease and most up to date learnings on the inflammasome mechanisms, drug design, and patient population
- Exploring the latest data, potential biomarkers, challenges, and future directions
Neuroscience 2022 Conference – Society for Neuroscience
November 2022, San Diego, California
Oral Presentation: The NLRP3 inhibitor RRx-001 crosses the blood brain barrier and alleviates neuroinflammation in experimental models of Parkinson’s disease
Alzheimer’s Association International Conference (AAIC) 2022
July 2022, San Diego, California
Poster: The direct NLRP3 inhibitor and Phase 3 anticancer agent, RRx-001, ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice
2022 Scientific Sessions of the National Lipid Association (NLA)
June 2022, San Francisco, California
Poster: The NLRP3 inhibitor and Nrf2 agonist, RRx-001, ameliorates non-alcoholic fatty liver disease (NAFLD/NASH) in rats
American Society of Clinical Oncology (ASCO) Annual Meeting
June 2022, Chicago, Illinois
Poster: Phase 2 pilot trial of RRx-001 as an anti-mucositis agent in head and neck cancer patients treated with chemoradiation (PREVLAR)
American Thoracic Society (ATS) Respiratory Innovation Summit
May 2022, San Francisco, California
Oral Presentation: Inflammation and Immunology: Feature Company Showcase
Poster: The ABCs of COVID-19 Related ARDS Treatment
Poster: N-VAX, a universal coronavirus vaccine
Poster: RRx-001, an NLRP3 inflammasome inhibitor, ameliorates bleomycin-induced pulmonary fibrosis
World Vaccine & Immunotherapy, World Antiviral Congress 2021
November 2021, San Diego, California
Oral Presentation: AdAPT-001, an oncolytic adenovirus armed with a TGF-beta “trap” fusion protein
EMBO Workshop “The inflammasomes: The next frontier” 2021
September 2021, Martinsried, Germany
Abstract: The direct NLRP3 inhibitor and Phase 3 anticancer agent, RRx-001, ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice
TGFβ for Immuno-Oncology Drug Development Conference 2021
January 2021, Virtual
Poster: AdAPT-001, a replication competent type 5 adenovirus carrying a TGF-β “trap”, reverses resistance to a PD-L1 inhibitor in an immunocompetent mouse model
American Society for Radiation Oncology (ASTRO) 2020
October 2020, Virtual
Oral Presentation: Results of a Randomized, Open Label, Multicenter Trial Assessing the Safety, Dose and Schedule of RRx-001 (R001) in Reducing Severe Oral Mucositis (SOM) in Patients Receiving Chemoradiation (CRT) for Oral Cavity/oropharynx Squamous Cell Carcinoma (OSCC)
American Society of Clinical Oncology (ASCO) Annual Meeting 2020
June 2020, Virtual
Poster: Results of a randomized, open-label, multicenter trial to assess the safety, dose, and schedule of RRx-001(001) in reducing incidence, severity and duration of severe oral mucositis (SOM) inpatients receiving concomitant chemoradiation (CRT) for advanced.
Abstract: Phase 2 Expansion Cohort in Colorectal Cancer to Evaluate the Safety and Tolerability of RRx-001 Blood Mix.
Abstract: Phase 1 Pilot Study of RRx-001 + Nivolumab in Patients with Traditionally Non-Checkpoint Inhibitor-Responsive Cancers (PRIMETIME).
Abstract: DCE-MRI Evaluation of Ten Patients with Brain Metastases Treated with RRx-001, a CD47 and PD-L1 Downregulator, in a Phase 1/2 Trial Called BRAINSTORM.
Abstract: A phase 3 trial-in-progress called REPLATINUM that compares RRx-001 + a platinum doublet to a platinum doublet in third-line or beyond small cell lung cancer.
Abstract: Correlation of decreased expression of PD-L1 on circulating tumor cells and clinical benefit in SCLC Patients treated with RRx-001, a CD47 downregulator, in a phase II trial.
Abstract: Phase 1 Study (PAYLOAD) of RRx-001 + Irinotecan in Patients with Advanced Solid Malignancies.
American Association for Cancer Research (AACR) Annual Meeting 2019
March 2019, Atlanta, Georgia
Abstract: Response to RRx-001 in SCLC is positively correlated with a reduction in CD206(+) HLA-DR(-/low) myeloid-derived suppressor cells
Society for Immunotherapy of Cancer (SITC) Annual Meeting 2018
November 2018, Washington, D.C.
Abstract: BETATRAP, a replication competent type 5 adenovirus carrying a TGF-beta trap, reverses resistance to a PD-L1 inhibitor in an immunocompetent mouse model
Society for Neuro-Oncology (SNO) 2018
November 2018, New Orleans, Louisiana
Abstract: Initial clinical and advanced imaging outcomes from a multi-institutional phase 1 dose-escalation trial of RRx-001 plus whole brain radiation for patients with brain metastases
American Society for Radiation Oncology (ASTRO) 2018
October 2018, San Antonio, Texas
Abstract: Initial clinical and advanced imaging outcomes from a multi-institutional phase I dose-escalation trial of RRx-001 plus whole brain radiation for patients with brain metastases
American Society of Clinical Oncology (ASCO) Annual Meeting 2018
June 2018, Chicago, Illinois
Abstract: QUADRUPLE THREAT: A phase II trial of RRx-001 followed by etoposide-platinum re-challenge in previously treated small cell lung cancer
Genitourinary Cancers Symposium 2018
February 2018, San Francisco, California
Abstract: Sensitization of neuroendocrine prostate cancer by RRx-001
ASCO-SITC Clinical Immuno-Oncology Symposium 2018 February 2018, Virtual
February 2018, Virtual
Abstract: RRx-001 is a phase III aerospace-derived small molecule that immunonormalizes the tumor microenvironment
Radiation Research Society (RRS) Annual Meeting 2017
October 2017, Cancun, Mexico
Abstract: Radioprotective effects of RRx-001 on the pathophysiology of the hematopoietic system using a murine radiation model
American Association for Cancer Research (AACR) Annual Meeting 2017
April 2017, Washington, DC.
Abstract: The immunomodulatory anticancer agent RRx-001 induces a vaccine-like interferon response through epigenetic induction of viral mimicry
Abstract: Epigenetic and biological effects of 5-azacytidine and RRX-001 on DLD-1 colorectal cancer cell lines
Abstract: Phase II clinical trial patient responses to the macrophage activating agent RRx-001 correlate to TGF-β pathway activation and markers for fibrosis
American Association for Cancer Research (AACR) Annual Meeting 2016
April 2016, New Orleans, Louisiana
Abstract: Enhanced uptake and accumulation of temozolomide and irinotecan in orthotopically-implanted gliomas by vascular priming with RRx-001
Abstract: RRx-001 is effective in temozolomide-sensitive and resistant GBM
Abstract: Improved statistical approaches that account for pseudoprogression in preclinical studies of RRx-001 with immunotherapies
American Society of Hematology (ASH) 2015
December 2015, Orlando, Florida
Oral Presentation: The hypoxia-selective epigenetic agent, RRx-001, triggers apoptosis and overcomes drug-resistance in multiple myeloma cells
AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics 2015
November 2015, Boston, Massachusetts
Abstract: RRx-001 combined with anti-PD-L1 antibody increases the complete response rate in a preclinical myeloma model
Stem Cells Regenerative Medicine Congress 2015
September 2015, Washington, D.C.
Invited Presentation: Restoring efficacy of immunotherapy treatments in oncology with radical oxygen and nitrogen based epigenetic drugs
AACR, Chromatin and Epigenetics in Cancer 2015
September 2015, Atlanta, Georgia
Abstract: RRx-001, a novel epigenetic modulator: Resensitization to previously failed therapy in the ongoing Phase 2 colorectal cancer study, “ROCKET”
International Society for Magnetic Resonance in Medicine (ISMRM) 2015
May 2015, Toronto, Canada
Abstract: RRx-001 oxidation of redox sensitive protein thiols in tumors measured by Gd-LC7-SH enhanced MRI in preclinical tumor models
American Association for Cancer Research (AACR) Annual Meeting 2015
April 2015, Philadelphia, Pennsylvania
Abstract: Early results from a phase 2 study of RRx-001, a novel, triple epigenetic inhibitor, showing resensitization to irinotecan in colorectal cancer
13th International Congress on Targeted Anticancer Therapies (TAT) 2015
March 2015, Paris, France
Abstract: Early results: “ROCKET” a phase II study of RRx-001, a novel triple epigenetic inhibitor, resensitization to irinotecan in colorectal cancer
Clinical Epigenetics International Meeting (CLEPSO) 2015
March 2015, Düsseldorf, Germany
Abstract: Early results from a phase 2 study of RRx-001, a novel epigenetic modulator, show resensitization to irinotecan in colorectal cancer
4th International Workshop on Nitric Oxide in Cancer Therapy 2015
March 2015, Seville, Spain
Invited Presentation: Early results from a phase 2 study of RRx-001, a novel, triple epigenetic inhibitor, showing resensitization to irinotecan in colorectal cancer
AACR Translation of the Cancer Genome Conference 2015
February 2015, San Francisco, California
Abstract: RRx-001, a novel first in class epigenetic modulator, ‘episensitizes’ colorectal patients to FOLFIRI: Preliminary resensitization data from the Phase 2 “ROCKET” study
17th Annual Symposium on Anti-Angiogenesis and Immune Therapies 2015
Feb 2015, La Jolla, California
Abstract: RRx-001, a novel first in class epigenetic modulator, ‘episensitizes’ colorectal patients to FOLFIRI: Preliminary resensitization data from the phase 2 “ROCKET” study
International Society For Extracellular Vesicles (ISEV) 2014
October 2014, San Diego, California
Abstract: RRx-001 an EXO-based epigenetic anti-cancer agent in phase 2 clinical trials
American Association for Cancer Research (AACR) Annual Meeting 2014
Apr 2014, San Diego, California
Abstract: Molecular imaging of RRx-001-induced oxidative stress in Nrf2-luciferase expressing SCC VII tumors in mice
Abstract: RRx-001 inhibits glucose erythrocyte and tumor glucose 6-phosphate dehydrogenase
Abstract: RRx-001 oxidation of redox sensitive protein thiols in tumors measured by Gd-LC7-SH enhanced MRI in preclinical tumor models
16th International Symposium on Anti-Angiogenic Therapy 2014
February 2014, La Jolla, California
Abstract: Resensitization to previous chemotherapy with the novel hypomethylating anticancer agent RRx-001